Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy
Abstract Background Poorly differentiated midline carcinoma with a translocation between chromosomes 15 and 19, i.e.t(15;19), has been recognized as a distinct clinical entity for over a decade.This tumor affects young individuals, shows a rapidly fatal clinical course despite intensive therapy.The t(15;19) results in the fusion oncogene BRD4-NUT.I